Analysis of PFAS(Forever Chemicals) Exposure on the Rist of Cancer Development

Presenter: Aleezah Khaliq, Neuroscience, Global Public Health Scholars

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I pursued my practicum project with the Georgetown Lombardi Comprehensive Cancer Center in a clinical bioinformatics and computational lab. My project focused on investigating the carcinogenicity of per-fluoryl-alkyl substances which are synthetic chemicals found in the environment and everyday items. We conducted a multi-omics (genomics, transcriptomics, proteomics, metabolomics) analysis to identify altered pathways, genes, and biomarkers that elucidate possible mechanisms of carcinogenicity. Based on our analysis, we assessed genes and biomarkers as therapeutic targets and proposed therapies to reduce the effects. Through this experience, I engaged in the various parts of the scientific process, expanded my knowledge of molecular biology, and learned how to use several bioinformatics softwares and technology. Our research contributes to the greater epidemiological evidence of PFAS exposure and its adverse effects, specifically for cancer. Additionally, several of the biomarkers identified have therapeutic potential and can be targeted for treatments that can reverse the negative effects of PFAS for exposed populations. My work and my host site's work aims to benefit individuals at risk for cancer and those who are highly exposed to PFAS chemicals whether that be due towhere their occupation is, their use of appliances and products that may contain PFAS, or other outlets of exposure. The Lombardi Comprehensive Cancer Center’s mission is to conduct research that provides a greater understanding of the causes of cancer and how it affects the population of D.C. My research with LCCC aims to advance their mission by investigating known carcinogens and developing preventative measures that can be implemented to reduce the negative effects.