Cell Biology & Molecular Genetics Ling Lab Research

Presenter: Wendy Liu, Psychology & Neurobiology, Global Public Health Scholars

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For my practicum project, I completed a research internship in the Department of Cell Biology and Molecular Genetics as a part of the Ling lab. My project investigates an aminoacyl-tRNA synthetase mutant strain of C. elegans which displays significant developmental delays in both egg and growth phase. The project investigates whether the mutation directly causes changes in fidelity and lifespan due to the mutation being characterized in patients with neurological and developmental diseases. Under the supervision of my mentor, I performed multiple wet lab experiments, such as running PCRs, western blots, and maintaining C. elegans strains. I learned how to interpret data, problem-solve, and create experimental designs. I also learned how the mechanisms we are studying relate to broader health issues, such as how these defects can lead to developmental and neurological diseases. The practicum helped me understand the role research plays in developing treatments for at-risk populations. Learning about the cellular mechanisms behind these diseases helped me understand population health by relating these diseases to certain influential factors such as environment, culture, and access to healthcare. Many global health challenges stem from genetic mutations of protein synthesis pathways, which can lead to diseases such as birth defects, cystic fibrosis, and Alzheimer’s, which decreases quality of life and lifespan. Lack of access to adequate healthcare can prevent patients from receiving treatment. However, studying these mutations can help us identify the genetic basis of these diseases, leading to earlier diagnoses and drug developments. This knowledge is crucial in preventing and treating widespread diseases.