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Studying Substance Addiction Through Animal Modeling

Presenter: Megan Burke, Molecular, Cellular and Physiological Neuroscience, Global Public Health Scholars

 
 
 

For my practicum I worked in the Li Lab in the Psychology Department here at the University of Maryland. The Li Lab’s work focuses on studying neural responses to drug taking, addiction, withdrawal, and relapse, in an effort to eventually create better treatments for drug addiction. I am responsible for helping to care for the animals, assist with running programs to train them to self-administer the drug, assist with testing for relapse, and review literature to help determine new directions for our research. After euthanasia, I often prepare slides with brain tissue in order to allow for imaging and molecular processing. During this, we use scientific methods such as polymerase chain reaction (PCR), which allows us to see which genes are expressed in certain brain regions. By understanding different genes’ roles in addiction, this can help us better tailor future studies to manipulate these genes. Overall, this has a strong public health application, as drug addiction has been an issue for many communities for a long time, and can have an impact on physical and mental health.

6 comments

6 Comments


Angie Murillo
Angie Murillo
May 06, 2021

Hi Megan, I found your presentation really interesting, especially given the current state of the world. In your presentation, you stated that social interactions with other people can help mitigate addiction. Due to the COVID-19 pandemic, many people have isolated themselves according to quarantine practices, so what solution can you propose to help those suffering from addiction in quarantine?

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Megan Burke
Megan Burke
May 07, 2021
Replying to

Hi Angie!! Thanks so much for watching. This is definitely a difficult question given the state of the pandemic, and that's part of the reason why social reward seeking research is so important right now! I think it's hard to give a clear cut solution at the moment, but I would suggest that more research is conducted into if virtual social interaction gives similar rewarding effects as in-person, and this information could inform situations like we are currently experiencing.

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hgauck
May 05, 2021

Hey Megan! I think your research is very interesting and I liked how you included future directions for your research! Do you think you'll continue with this lab and keep contributing to those future efforts?

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Megan Burke
Megan Burke
May 07, 2021
Replying to

Hi, thanks so much for watching!! Yes, I am very excited to be continuing in the lab for the rest of my time at the University of Maryland!

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Nikki Nguyen
Nikki Nguyen
May 05, 2021

Hi Megan. Your research seems really interesting. I also found the idea of having mice associate the cue light and tone to the drug injection was clever. How do you want to use this information in the future?

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Megan Burke
Megan Burke
May 07, 2021
Replying to

Hi Nikki! So this is a relatively typical feature in operant conditioning, and it's important for all sorts of cue-association. It's used to help the animal associate several different things together, and can be used to trigger relapse, measure incubation of craving, and more!

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